Selected citations for atipamezole hydrochloride include. Inhalation remove person to fresh air and keep comfortable for breathing. Product1 can be produced directly from 8 by making its hcl salt and hydrogenating the salt over pdc. Chemical name common name and synonyms cas number % atipamezole hydrochloride imidazole derivative 104075481 0. The citations listed below are publications that use tocris products. In case of accidental eye exposure, flush with water for 15 minutes. The atipamezole dose for the reversal of iv dexdomitor or domitor is 3750 mcgm 2. Atipamezole given at 3, 10, and 30 microgramskg shortened the time from onset of lateral recumbency to standing to 40. The chemical name is 42ethyl2,3dihydro1hinden2yl1himidazole hydrochloride. Synonyms atipamezole hcl unii 2w4279571x cas number 104075481 weight average. Ghs safety data sheet conforms to regulation ec no 19072006, article 31. Meclizine hydrochloride chewable tablets msds msdsdigital. Atipamezole is an imidazole that potently antagonizes the.
It has also been researched in humans as a potential antiparkinsonian drug. The handbook of receptor classification and signal transduction is a reference for scientists, researchers, educators, and the like. Highly selective and specific antagonism of central and peripheral alpha 2adrenoceptors by atipamezole. Atipamezole hydrochloride is a medicine available in a number of countries worldwide. Citations are publications that use tocris products.
Blood samples n19 for haematology and serum chemistry were. Safety data sheet 2dimethylaminoethanethiol hydrochloride. Studies indicate that atipamezole hydrochloride competitively antagonizes clonidine hydrochloride sc203002 and medetomidine hydrochloride sc204073 at presynaptic. Antisedan alzane antisedan atipamezole hydrochloride injectable.
Therefore, this immobilisation and reversal protocol would subject impalas to possible predation or conspecific aggression. Material safety data sheet additin rc 9505 440d rhein chemie corporation 1014 whitehead road ext. It contains over 100 entries covering such topics as intracellular signaling enzymes and receptors, signal transduction, ion channels, nonpeptide receptors, synthesis and metabolism, peptide receptors and peptide metabolism, protein kinase, serine, threonine. Grade 9015683 atipamezole hcl 104075481 atorvastatin calcium 344423989 atropine sulfate 5908996 azithromycin dihydrate 117772700 baclofen 14470 betamethasone acetate 987246. Benzalkonium chloride 5% safety data sheet date of issue 24082009. This comes out of solution easily, even with sonicating. Oct 23, 2012 atipamezole was tolerated in healthy dogs receiving 10. Accidental release measures spill absorb with an inert material and put the spilled material in an appropriate waste disposal. Studies indicate that atipamezole hydrochloride competitively antagonizes clonidine hydrochloride sc203002 and medetomidine hydrochloride sc204073 at. Atipamezole hcl mpv1248 hydrochloride cas 104075481. The material safety data sheet msds contains more detailed occupational safety information. A veterinary drug used to reverse the sedative and analgesic effects of the drugs dexmedetomidine and medetomidine. Antagonistic effect of atipamezole on xylazineinduced.
The handbook of receptor classification and signal transduction. Hmis and nfpa ratings are provided by rhein chemie corporation as a customer service. Signs were doserelated and included excitement, panting, trembling, vomiting, soft or liquid feces and scleral injection. Antisedan atipamezole hydrochloride is a synthetic. Jun 11, 2019 the molecular formula is c 14 h 16 n 2 hcl and structural formula is. It provides for a wellcontrolled and predictable recovery resulting in accelerated re. Environmental fate ecotoxicology human health a to z index home.
Reversal of xylazineinduced sedation in dairy calves with. Other studies have investigated the effects of drugs on the metabolic rate. Product name 5aminolevulinic acid hydrochloride cas number 5451092 ec number 2266795 chemical formula c. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Ati dose ratios ww for reversal and the antagonistic effect of xylazine was evaluated. European inventory of existing commercial chemical substances einecs not listed. Atipamezole hydrochloride safety data sheet section 2. Administration of atipamezole causes transient changes in heart rate and blood pressure. Twentyeight animals were given atipamezole iv 15100 min after darting, and the effects of the antagonist were evaluated. Dispose of this material and its container to hazardous or special waste collection point. Material safety data sheet zoecon altosid liquid larvicide concentrate manufacturer. Information on toxicological effects acute toxicity components species test results atipamezole hydrochloride cas 104075481 intramuscular acute.
Atipamezole hydrochloride sterile injectable solution. Atipamezole hydrochloride can be absorbed and may cause irritation following direct exposure to skin, eyes, or mouth. Revertidine atipamezole hydrochloride injection, solution. A list of us medications equivalent to atipamezole hydrochloride is available on the website. Alternatively, acid hydrolysis of 8 removes the trityl group to form dione 9, recovered as a white crystalline solid in 76. The concentration of antisedan is formulated so that the volume of injection is the same ml for. It has also been undergone research as a potential antiparkinsonian drug for humans. Atipamezole hydrochloride cas 104075481 msds download. Noncontrolled, exempt inventory status this product is not listed on the us tsca inventory. Antisedan atipamezole hydrochloride injection, solution.
Atipamezole hydrochloride sterile injectable solution pfizer inc. Buy adrenergic receptor inhibitor atipamezole hcl mpv1248 hydrochloride from abmole bioscience. Crude atipamezole is isolated as its hcl salt in 26. Atipamezole is highly selective for the alpha2 noradrenergic receptor, and was used as a reference compound during behaviral testing. Atipamezole hydrochloride sterile injectable solution pfizer inc section 6 accidental release measures continued container for treatment and disposal. Tocris bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years experience in the industry. Drowsiness was found in calves given the lowest dosage of atipamezole 3 microgramskg after the calves stood. To report adverse reactions in users or to obtain a copy of the msds for this product call 18885909839.
Antisedan is administered intramuscularly regardless of the route used for dexdomitor or domitor. Twentynine freeranging norwegian cattle were captured with xylazine n20 or medetomidine n9 using a tranquilizing gun, and the time from darting to recumbency induction time was recorded. Safety data sheet 5aminolevulinic acid hydrochloride. Safety data sheet according to federal register vol. Pb revertidine 221 1502 0 modern veterinary therapeutics. Atipamezole hydrochloride cas 104075481 scbt santa. The material safety data sheet msds contains more detailed occupational. The atipamezole dose for the reversal of im dexdomitor or domitor is 5000 mcgm 2.
Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Mar 20, 2020 antisedan atipamezole hydrochloride is a synthetic. Atipamezole hydrochloride cas 104075481 cayman chemical. Clinical use of this drug has caused nervousness, excitation, vomiting, diarrhea. It is generally licensed to reverse medetomidine in dogs and cats but has been used to antagonize other. Atipamezole indicated for the reversal of the sedative and analgesic effects of dexdomitor dexmedetomidine and domitor medetomidine. Pdf reversal of xylazineinduced sedation in dairy calves. Conversely, atipamezole is known to provide a rapid reversal of xylazineinduced sedation and immobilization 51, 52. Interquim mexico offers a wide range of products which includes atipamezole hydrochloride.
Disclaimer pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it is provided in good faith, it is without a warranty of any kind, expressed or implied. The molecular formula is c 14 h 16 n 2 hcl and structural formula is. May cause eye, skin, or respiratory system irritation. Atipamezole hydrochloride imidazole derivative 104075481 0. Material may be irritating to the mucous membranes and upper respiratory tract. Page 16 safety data sheet according to 19072006ec, article 31 printing date 01. Description of first aid measures general information get medical adviceattention if you feel unwell.
Yohimbine and tolazoline have been used primarily to reverse xylazineinduced sedation. After fully dissolving in dmso, add water slowly and continue to vortex or sonicate. Buy atipamezole hydrochloride cas 104075481, a selective. Antisedan specific reverser of medetomidine for dogs. Sr0212 personal precautions wear suitable gloves and eyeface protection. Identification of the substancemixture and of the companyundertaking product name. Product name 2 dimethylaminoethanethiol hydrochloride cas number 242449 ec number 2362216 chemical formula c. The handbook of receptor classification and signal. Atipamezole hydrochloride safety data sheet supersedes revision. Amiodarone hcl 19774824 amitriptyline hcl 549188 anastrozole 120511731 arginine hcl 1119342 artemether 71963774 asparaginase, inj.
Atipamezole hydrochloride is hydrochloride form of atipamezole. Incinerate the material under controlled conditions in an approved incinerator. In case of accidental skin exposure, wash with soap and water. Dailymed antisedan atipamezole hydrochloride injection. Dairy calves immobilized with xylazine xyl were given atipamezole hcl ati at different xyl.
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